Nicotiana quadrivalvis is a species of wild tobacco known by the common name Indian tobacco. It is native to the western United States, where it grows in many types of habitat. It is a bushy, sprawling annual herb growing up to two meters in maximum height. The lower leaf blades are up to 15 centimeters long and are borne on short petioles, the upper smaller and sessile on the stem. The inflorescence is an array of several white, greenish, or purple-tinged flowers with tubular throats up to 5 centimeters long. The base of each is enclosed in a ridged calyx of sepals. The flower face may be 5 centimeters wide. The fruit is a capsule up to 2 centimeters in length.