Cissus trifoliata, known variously as possum-grape, sorrelvine, or vine-sorrel, is a New World plant species in the grape family. It is native to southern and central Florida in the U.S.; Quintana Roo, Yucatán, Michoacán, Oaxaca, Puebla, Veracruz, Baja California, Chihuahua, Coahuila, Durango, Nuevo León, San Luis Potosí, Sinaloa, Sonora, and Tamaulipas in Mexico; Venezuela, Colombia and perhaps in Ecuador (Loja). It is also dispersed among some islands in the Caribbean (Aruba, Bahamas, Cuba, Hispaniola, Jamaica, Puerto Rico, and St. Croix and St. Thomas in the U.S. Virgin Islands).