Lupinus nipomensis is a species of lupine known by the common name Nipomo Mesa lupine. It is endemic to the Guadalupe-Nipomo Dunes on the California Central Coast. Specifically, the plant is limited to the Guadalupe Dunes at the southern border of San Luis Obispo County. There are five to seven colonies growing in a strip of sand dunes measuring less than three square miles in area. These colonies are generally considered to make up a single population. The number of individual plants remaining has been observed to vary between 100 and 1,800, its abundance depending on the amount of rainfall. This is a federally listed endangered species.