Knowltonia vesicatoria (Brandblaar) is an attractive, shade-loving plant of the family Ranunculaceae, that is indigenous to the southern parts of South Africa. This is one of at least ten species of Knowltonia that are native to South Africa. Knowltonia vesicatoria can be told apart from the other species by its leaves and stems being hairless, and by the slightly jagged, toothed margins of the leaves. It in turn has three subspecies: vesicatoria, humilis and grossa. Further east - in the Eastern Cape and Kwazulu-Natal - this plant's close relative Knowltonia capensis is rather more common.