Grevillea zygoloba is a shrub of the genus Grevillea native to an area in the Wheatbelt and Goldfields-Esperance regions of Western Australia. The erect shrub typically grows to a height of 1 to 2 metres (3.3 to 6.6 ft) and has glaucous branchlets. It has dissected subpinnatisect leaves with a blade that is 50 to 80 millimetres (2.0 to 3.1 in). It blooms between September and November and produces an axillary or terminal raceme irregular inflorescence with white or cream flowers with white styles. Later it forms viscid ellipsoidal glabrous fruit that are 5 to 7 mm (0.2 to 0.3 in) long.