Echium amoenum is a biennial or perennial herb indigenous to the narrow zone of northern part of Iran and Caucasus, where it grows at an altitude ranging from 60 to 2200 m. It is one of the important medicinal herbs in traditional Iranian medicine. E. amoenum have been advocated for variety of effects such as demulcent, anti-inflammatory and analgesic, especially for common cold, anxiolytic and sedative.