Plectrohyla matudai (common name: Matuda's spikethumb frog) is a species of frog in the family Hylidae. It is found along the Pacific slopes from southeastern Oaxaca, Mexico, through south-central Guatemala (Las Nubes range); also in the Grijalva Depression in western Guatemala and on Cerro Azul in northwestern Honduras. It is named after Eizi Matuda, Japanese–Mexican botanist. Its natural habitats are pine-oak and cloud forests and is typically found in low vegetation along small mountain streams. It is threatened by habitat loss and disturbance. Chytridiomycosis is also a potential threat.