Calybites quadrisignella is a moth of the Gracillariidae family. It is found from Poland and Germany to Italy, Hungary and Romania, as well as Russia. The larvae feed on Rhamnus catharticus, Rhamnus frangula, Rhamnus imeritinus and Rhamnus saxatilis tinctorius. They mine the leaves of their host plant. The mine starts as a lower-surface, epidermal corridor, widening into a small full depth blotch in a vein axle. Most frass is concentrated in the axle. Older larvae live freely within a rolled leaf margin.