Synodontis woleuensis is a species of upside-down catfish native to Equatorial Guinea and Gabon. It was first described in 2008 by American zoologists John P. Friel and John P. Sullivan. The original holotypes were collected in the Woleu-Ntem Province, Gabon. The specific name "woleuensis" is derived from the Woleu River, where the specimens were originally collected.