Nesoryzomys indefessus narboroughi is a subspecies of Nesoryzomys indefessus, a rodent in the genus Nesoryzomys, from Fernandina Island in the Galápagos Islands. The only other subspecies occurred on Indefatigable Island, but is now extinct. Some consider the two to be distinct species, in which case the Fernandina form would be Nesoryzomys narboroughi. Another, larger, Nesoryzomys is also found on Fernandina—Nesoryzomys fernandinae.