Mondolfi's four-eyed opossum (Philander mondolfii) is a South American species of opossum found in Colombia and Venezuela, first described in 2006. It inhabits foothills of the Cordillera de Mérida and those on the eastern side of the Cordillera Oriental at elevations from 50 to 800 m. Populations in the two ranges may represent distinct subspecies. It is named after Venezuelan biologist Edgardo Mondolfi. Its fur is short and woolly. Its dorsal fur is gray, and its ventral fur is cream-colored. Its ears are colored at the tips. The spots above its eyes are large and conspicuous. The spots behind its ears are smaller but still conspicuous.