Eupithecia zygadeniata is a moth in the family Geometridae. It is found in North America, with records from Texas and Montana. Adults are very similar to Eupithecia indistincta, but the forewings have greyer ground colour, a smaller discal dot and possess numerous, rather indistinct oblique cross lines. Adults have been recorded on wing in June and July. The larvae feed within the seed capsules of Schoenocaulon texanum.