Neoliotomus is a genus of North American mammal from the Paleocene. It existed in the age immediately following the extinction of the last dinosaurs and was a member of the extinct order Multituberculata. It lies within the suborder Cimolodonta and the superfamily Ptilodontoidea. Other than that, its affinities are somewhat unclear. The genus Neoliotomus ("new Liotomus") was named by Jepsen G.L. in 1930, and is also known as Eucosmodon (partly).