Sepia tuberculata is a species of cuttlefish native to South African waters from Melkbosstrand (33°43′S 18°26′E / 33.717°S 18.433°E) to Knysna (34°03′S 23°03′E / 34.050°S 23.050°E). It lives in very shallow water to a depth of 3 m. It is endemic. The type specimen was collected off the coast of South Africa and is deposited at the Muséum National d'Histoire Naturelle in Paris.