Hemidactylus acanthopholis is a species of house gecko from the Tirunelveli in southern Tamil Nadu. Bearing a superficial resemblance to Hemidactylus maculatus, the species is usually found on large rocks or boulders. Growing 20–23 cm (7.9–9.1 in) in length, the species is an overall brown color, but has dark stripes on its back. It takes its name from the warty protuberances running along its dorsal surface.