Psilocybe zapotecocaribaea is a species of mushroom in the Strophariaceae family. The mushroom contains the medicinal compound psilocybin. It is in the section Zapotecorum of the genus Psilocybe, other members of this section include Psilocybe muliercula, Psilocybe angustipleurocystidiata, Psilocybe aucklandii, Psilocybe collybioides, Psilocybe kumaenorum, Psilocybe zapotecorum, Psilocybe kumaenorum, Psilocybe subcaerulipes, Psilocybe pintonii, Psilocybe moseri, Psilocybe zapotecoantillarum, and Psilocybe antioquiensis.