Pristimantis kelephus is a species of frog in the Craugastoridae family. It is endemic to Colombia and known from the Cordillera Occidental in Cauca, Chocó, and Valle del Cauca Departments, at elevations of 1,900–2,610 m (6,230–8,560 ft) asl. Its type locality is in El Cairo, Valle del Cauca Department. The specific name is derived from Greek kefephos, meaning leper, in reference to the rounded pustules on the dorsal surfaces that provide the impression of some disfigurement caused by leprosy.