Cosmibuena is a genus of flowering plants in the family Rubiaceae. The genus is native to Chiapas, Central America, and South America as far south as Brazil. These are succulent shrubs and trees, often growing as epiphytes. The leaves are oppositely arranged. The inflorescence is a terminal cluster or sometimes a solitary flower. The flowers are large, showy, and fragrant. They are white, fading yellow. They open at night and dry out and die the next day. The fruit is a woody capsule containing papery winged seeds. These plants grow in wet lowlands, mountain forests, and mangroves.