Hippotion osiris is a moth of the family Sphingidae. It is common throughout most of the Ethiopian Region, including Madagascar and the Seychelles. Occasional vagrants have been recorded from Spain. It is uncommon on the East African coast. This species is an occasional migrant. The larvae mainly feed on Vitis and Parthenocissus species, but have also been recorded on Richardsonia, Daucus, Rumex, Polygonum, Impatiens, Cissus, Ipomoea, Spathodea, Fuchsia and various Rubiaceae species.