Manduca tucumana is a moth of the family Sphingidae. It is known from Argentina and Bolivia. The wingspan is about 108 mm. It is similar in appearance to several other members of the Manduca genus, but a number of differences distinguish it from Manduca pellenia and Manduca scutata, to which it most closely compares, particularly in its distinctly paler head, thorax and forewing and the almost white discal spot, pale lines and fringe on the forewing upperside. The abdomen underside is somewhat buffish.