Orphnolechia neastra is a moth in the Depressariidae family. It was described by Meyrick in 1915. It is found in Guyana. The wingspan is about 11 mm. The forewings are purple-blackish with a white line from the middle of the costa to three-fifths of the dorsum, somewhat angulated in the middle. The hindwings are dark fuscous becoming blackish posteriorly. There is a moderate irregular white spot in the disc beyond the middle.