Ethmia macelhosiella is a moth in the Depressariidae family. It is found in the United States, including Missouri, Maryland, Pennsylvania and Oklahoma. The length of the forewings is 10.7-12.7 mm. The ground color of the forewings is whitish, sparsely to densely irrorated (speckled) with pale brownish. The ground color of the hindwings is pale brownish or dirty whitish. Adults have been recorded in October and November. The larvae feed on Phacelia species. They select cracks in or bore into the bark of logs ortrees to pupate.