Agonopterix sanguinella is a moth in the Depressariidae family. It was described by Busck in 1902. It is found in North America, where it has been recorded from Arizona, New Mexico and Nevada. The wingspan is about 21 mm. The forewings are grey, irrorated with black and with a carmine tinge, this carmine colour is more pronounced along the costa and apex. The base of the wing and costa are pale greyish ochreous, the former followed by and the latter narrowly edged with black. There are two black discal spots edged with a few carmine scales at the basal third and a white discal spot edged with carmine at the end of the cell. There is also a blackish dash from the discal spot at the end of the cell. The hindwings are light ochreous fuscous.