Agonopterix muricolorella is a moth in the Depressariidae family. It was described by Busck in 1902. It is found in North America, where it has been recorded from Colorado, eastern Oregon and eastern Washington. The wingspan is about 17 mm. The forewings are dark mouse grey with a purple tinge towards the apex and round the edges and also sprinkled with sparse black scales. The base and the basal part of the costa somewhat lighter than the rest of the wing. The hindwings are shining dark grey. The larvae feed on Lomatium macrocarpum, Lomatium grayi and Leptotaenia multifida.