Agonopterix eupatoriiella is a moth in the Depressariidae family. It was described by Chambers in 1878. It is found in North America, where it has been recorded from Illinois, Kentucky, Maryland, Michigan, Minnesota, Mississippi, Missouri, North Carolina, Ohio, Quebec, Tennessee and Wisconsin. The wingspan is about 24 mm. The forewings are dark to fuscous grey, dusted with blackish, forming small streaks along the costa. The hindwings are pale greyish, with a faint purplish lustre. The larvae feed on Eupatorium species, Actinomeris alternifolia and Carya ovata.