Megacraspedus centrosema is a moth of the Gelechiidae family. It was described by Meyrick in 1904. It is found in Australia, where it has been recorded from New South Wales and South Australia. The wingspan is 11-12 mm. The forewings are fuscous with a shining white costal streak from the base to the apex, narrowed towards the extremities, the lower edge straight and edged with dark fuscous. There is an undefined rather broad streak of white suffusion along the dorsum and termen. The hindwings are whitish-grey.