Gnorimoschema saphirinella is a moth in the Gelechiidae family. It was described by Chambers in 1875. It is widespread throughout North America, where it has been recorded from Alabama, Arizona, California, Colorado, Florida, Georgia, Illinois, Kansas, Mississippi, New Mexico, North Dakota, Oklahoma, Tennessee and Texas. The larvae feed on Ambrosia chamissonis, Ambrosia confertifolia and Ambrosia psilostachya. They mine the leaves of their host plants.