Dichomeris setosella is a moth in the Gelechiidae family. It was described by Clemens in 1860. It is found in North America, where it has been recorded from New York to Florida, Manitoba, eastern Kansas, Oklahoma, Texas and Kentucky. The larvae feed on Eupatorium and Vernonia species, as well as Verbesina virginica, Pinus strobus, Thuja occidentalis, Pluchea odorata and Ageratina altissima var. angustata.