Dichomeris serena is a moth in the Gelechiidae family. It was described by Meyrick in 1909. It is found in Bolivia. The wingspan is about 17 mm. The forewings are yellowish-brown, the costal edge sometimes pale yellowish. The stigmata is dark fuscous, with the plical obliquely beyond the first discal, the second discal larger and indistinctly edged with pale yellowish. There are some indistinct pale yellowish dots on the posterior part of the costa and termen. The hindwings are blackish-grey.