Holaxyra picrophanes is a moth in the Gelechiidae family. It was described by Meyrick in 1913. It is found in South Africa. The wingspan is about 15 mm. The forewings are silvery-white, the dorsal half tinged and sprinkled with pale fuscous. There is a moderately broad dark fuscous median longitudinal streak from the base to the apex, with the lower edge somewhat suffused. The hindwings are whitish-grey.