Dichomeris mesoglena is a moth in the Gelechiidae family. It was described by Meyrick in 1923. It is found in southern India. The wingspan is about 19 mm. The forewings are yellow-ochreous, sprinkled light bluish-grey, tending to form irregular strigulation. The base of the costa is dark bluish-fuscous, with oblique blackish costal strigulae from this to three-fourths, tipped blue-grey. There is also a small round blackish spot in the middle of the disc and a dark fuscous terminal fascia, very narrow at the apex and the tornus, the remainder triangularly dilated, the angle connected by a light blue-greymark with the costa at four-fifth. The hindwings are dark grey.