Corynebacterium urealyticum is a bacterial species of the Corynebacterium genus. It is not commonly found in healthy people. It is, however, an important isolate when found in conjunction with a urinary tract infection. In contrast to acid-producing bacteria like Escherichia coli, C. urealyticum, as the name implies, secretes urease enzyme which is strong enough to make urine alkaline. This can lead to the formation of struvite calculi or renal stones.Risk factors associated with this bacterium include, immunosuppression, underlying genitourinay disorders, as well as antibiotic therapy. There are other urease-producing cornybacteria that are associated with urinary tract infections, but C. urealyticum is the most common.