Koanophyllon is a genus of plants in the sunflower family. They are perennials and shrubs (rarely vines or trees) and are native to South America, Central America, the West Indies, Mexico, with a few species range extending into the United States. The flowers are white to pinkish (rarely purple). Cuba alone has 21 endemic species, seven of which only grow in serpentine soils, and some of which accumulate minerals such as nickel and manganese.