Padillasaurus is an extinct genus of brachiosaurid sauropod known from the Early Cretaceous (Barremian stage) Paja Formation in Colombia. It contains a single species, Padillasaurus leivaensis, known only from a single partial axial skeleton. Padillasaurus represents the first South American brachiosaurid ever discovered and named. Before its discovery, the only known brachiosaurid material on the continent was from the Jurassic period, however being very fragmentary.