Pachygenelus is an extinct genus of tritheledontid cynodont. Fossils have been found from the Karoo basin in South Africa and date back to the Early Jurassic. Pachygenelus had both an articular-quadrate and dentary-squamosal jaw joint characteristic of ictidosaurs. Only mammals possess the dentary-squamosal articulation, while all other tetrapods possess the typical arcticular-quadrate articulation. Thus the jaw of Pachygenelus can be seen as transitional between non-mammalian synapsids and true mammals. Another feature of Pachygenelus that is shared with mammals is plesiomorphic prismatic enamel, or enamel arranged into strengthened prisms. The upper and lower tooth rows occluded with one another, although not as close as what is seen in true mammals. Wear facets are present on the lingua