Sineoamphisbaena is an extinct genus of squamate of uncertain phylogenetic placement. Its fossils are known from the Late Cretaceous deposits in Inner Mongolia, China. Wu et al. (1993), Wu et al. (1996) and Gao (1997) proposed and argued that it was the oldest known amphisbaenian; this, however, was challenged by other authors, such as Kearney (2003) and Conrad (2008), who instead assigned Sineoamphisbaena to the group of squamates variously known as Macrocephalosauridae, Polyglyphanodontidae or Polyglyphanodontia.