Toxodontidae is an extinct family of notoungulate mammals known from the Oligocene through the Pleistocene of South America, with one genus, Mixotoxodon, also known from the Pleistocene of Central America and southwestern North America (Texas). They somewhat resembled rhinoceroses, and had teeth with high crowns and open roots, suggesting that they often fed on tough pampas grass. However, isotopic analyses have led to the conclusion that the most recent forms were grazing and browsing generalists.