Ichthyothere is a genus of flowering plants, found in parts of South America (the Amazon) and Central America. The name ichthyothere literally translates as fish poison. These plants' active constituent is a chemical called ichthyothereol, which is a polyyne compound that is highly toxic to fish and mammals. Ichthyothere terminalis leaves have traditionally been used to make poisoned bait by indigenous peoples of the lower Amazon basin.