Centrolene is a genus of glass frogs in the family Centrolenidae. The adult males are characterized by having a humeral spine, as most members of this family. The delimitation of this genus versus Cochranella is not fully resolved, and some species formerly in Centrolenella — which is nowadays synonymized with Centrolene — are now in Hyalinobatrachium. The genus is known as "giant glass frogs". But this is merely relative to the rest of their family, which contains numerous extremely diminutive species.